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Stem Cells for Urinary Incontinence: Functional Differentiation or Cytokine Effects?
Bradley C Gill1, Daniel Z Sun2, Margot S Damaser3
1Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Urology
|January 18, 2018
Summary
Minimally invasive stem cell therapy offers a promising nonsurgical option for stress urinary incontinence. This review examines how stem cells function, whether through tissue regeneration or secreted factors, to treat this condition.
Area of Science:
- Regenerative Medicine
- Urology
- Cell Biology
Background:
- Stress urinary incontinence (SUI) is a common condition affecting many women.
- Current treatments for SUI have limitations, driving the need for novel therapeutic approaches.
- Minimally invasive stem cell therapy is emerging as a potential nonsurgical treatment for SUI.
Purpose of the Study:
- To explore the fate of therapeutic stem cells used in SUI treatment.
- To investigate the relationship between stem cell fate and their mechanism of action in SUI.
- To review current clinical and basic science research on stem cell therapy for SUI.
Main Methods:
- Literature review of clinical trials and basic science research.
- Analysis of studies investigating stem cell differentiation and factor secretion.
- Exploration of stem cell fate following periurethral injection.
Main Results:
- Stem cell therapy shows potential efficacy for SUI through both local and systemic administration.
- Research findings are varied regarding whether stem cells achieve therapeutic effects via differentiation or secreted factors.
- The transient presence and regenerative factor secretion of stem cells are key areas of investigation.
Conclusions:
- Understanding stem cell fate is crucial for elucidating their therapeutic mechanisms in SUI.
- Further research is needed to optimize stem cell therapies for SUI.
- Stem cell therapy represents a promising avenue for nonsurgical management of SUI.
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