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The value of real-time myocardial contrast echocardiography for detecting coronary microcirculation function in

Lulu Sun, Zilong Wang, Tongda Xu

  • 1Institute of Cardiovascular Disease Research, Xuzhou Medical University, Jiangsu Province-P. R. China. dongyeli@xzhmu.edu.cn.

Anatolian Journal of Cardiology
|January 18, 2018
PubMed

Insights

Real-time myocardial contrast echocardiography (RT-MCE) effectively detects coronary microcirculation (CM) dysfunction in coronary artery disease (CAD). This method reveals CM function deterioration in both ischemic and non-ischemic areas of CAD patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Echocardiography

Background:

  • Coronary artery disease (CAD) impacts myocardial microcirculation (CM).
  • Assessing CM function is crucial for understanding CAD progression.
  • Current diagnostic methods may have limitations in evaluating microvascular function.

Purpose of the Study:

  • To evaluate the diagnostic value of real-time myocardial contrast echocardiography (RT-MCE).
  • To detect coronary microcirculation (CM) function in patients with coronary artery disease (CAD).
  • To correlate RT-MCE findings with coronary angiography (CAG) and Gensini scores.

Main Methods:

  • Sixty-five patients underwent RT-MCE and coronary angiography (CAG).
  • Patients were categorized into CAD and non-CAD groups.
  • Myocardial blood volume (A), blood flow velocity (ß), and mean blood flow (Axß) were quantified using RT-MCE. Segmental analysis identified ischemic and non-ischemic areas in CAD patients.

Main Results:

  • RT-MCE identified significant differences in A, ß, and Axß between non-CAD, CAD, ischemic, and non-ischemic groups.
  • Receiver operating characteristic (ROC) curve analysis showed areas of 0.85 for A, 0.79 for ß, and 0.83 for Axß.
  • These parameters demonstrated significant correlations with Gensini scores in CAD patients.

Conclusions:

  • RT-MCE is valuable for assessing CM function in CAD patients.
  • CM function deterioration is evident in both ischemic and non-ischemic myocardial regions.
  • The degree of CM dysfunction is more pronounced in ischemic areas compared to non-ischemic areas.
Abstract

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