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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative

Jessica L Christenson1, Jane B Trepel2, Haythem Y Ali3

  • 1Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Hormones & Cancer
|January 18, 2018
PubMed

Insights

Androgen receptor (AR) targeted therapies show promise for a subset of triple-negative breast cancers (TNBCs). Further research is defining AR

Area of Science:

  • Oncology
  • Endocrinology
  • Cancer Biology

Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapies, with chemotherapy as the primary treatment.
  • The androgen receptor (AR) is expressed in a subset of TNBCs, suggesting it as a potential therapeutic target.
  • The precise role and dependency of TNBC on AR, especially after treatment, require further elucidation.

Purpose of the Study:

  • To review preclinical and clinical data on AR-positive (AR+) TNBC.
  • To explore the influence of AR on cancer stemness and immune regulation in TNBC.
  • To discuss challenges in AR detection and novel therapeutic strategies targeting AR and androgen production.

Main Methods:

  • Review of existing preclinical and clinical studies on AR+ TNBC.
  • Discussion of emerging methods for assessing AR status.
  • Analysis of AR's role in stemness, immune response, and therapeutic resistance.

Main Results:

  • AR plays a multifaceted role in AR+ TNBC, influencing stemness and immune evasion.
  • Monitoring AR protein levels presents challenges, necessitating improved detection methods.
  • Combined inhibition of androgen production and AR signaling is a potential therapeutic avenue.

Conclusions:

  • Targeting AR and androgen production offers a promising alternative or addition to chemotherapy for select TNBC patients.
  • Further characterization of AR's mechanisms in TNBC is crucial for optimizing treatment strategies.
  • New therapies targeting AR may expand treatment options for patients with limited alternatives.

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