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Updated: Feb 15, 2026

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
Published on: February 28, 2014
In Utero MRI of Mouse Embryos
Jiangyang Zhang1, Dan Wu2, Daniel H Turnbull3,4,5
1Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, New York University (NYU) School of Medicine, New York, NY, USA.
Abstract:
Genetically engineered mouse models are used extensively as models of human development and developmental diseases. Conventional histological approaches are static and two-dimensional, and do not provide a full understanding of the dynamic, spatiotemporal changes in developing mouse embryos. Magnetic resonance imaging (MRI) offers a noninvasive and longitudinal approach for three-dimensional in utero imaging of normal and mutant mouse embryos. In this chapter, we describe MRI approaches that have been developed for imaging the living embryonic mouse brain and vasculature. Details are provided on the animal preparation and setup, MRI equipment, acquisition and reconstruction methods that have been found to be most useful for in utero MRI, including examples of applications to fetal mouse neuroimaging.
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