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[Correlation between the parameters of acoustic cardiography and BNP, LVEF and cardiac function grading in patients
1Department of Cardiology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China.
Insights
New Acoustic Cardiography parameters correlate with brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF). These findings support Acoustic Cardiography as an assistant tool for diagnosing and evaluating heart failure.
Area of Science:
- Cardiology
- Medical Diagnostics
- Biomedical Engineering
Background:
- Heart failure diagnosis relies on clinical assessment, biomarkers like BNP, and imaging like LVEF.
- Novel diagnostic tools are needed to improve the accuracy and efficiency of heart failure assessment.
- Acoustic Cardiography (AC) offers a non-invasive method to evaluate cardiac mechanics.
Purpose of the Study:
- To investigate the relationship between new Acoustic Cardiography (AC) parameters and established heart failure indicators.
- To assess the utility of AC parameters in correlation with brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF).
- To determine if AC parameters can aid in the grading of cardiac function in heart failure patients.
Main Methods:
- 168 heart failure patients (NYHA classes I-IV) and 87 healthy controls underwent AC testing.
- Measurements included QRS duration, electromechanical activation time (EMAT), EMAT%, systolic dysfunction index (SDI), third heart sound (S3), and left ventricular systolic time (LVST).
- Data were analyzed for correlations with brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), and cardiac function grading.
Main Results:
- AC parameters (EMAT%, EMAT, SDI, S3) showed significant differences across cardiac function grades (P<0.05).
- Positive correlations were found between QRS duration, EMAT%, SDI, S3 and BNP; negative correlation with LVST and BNP.
- Negative correlations were observed between QRS duration, EMAT%, SDI, S3 and LVEF; positive correlation with LVST and LVEF.
Conclusions:
- Acoustic Cardiography parameters (EMAT%, EMAT, SDI, S3) are significantly correlated with BNP and LVEF.
- These AC parameters demonstrate a strong relationship with cardiac function grading in heart failure.
- Acoustic Cardiography shows promise as an adjunctive tool for diagnosing and evaluating heart failure.
Abstract:
Objective: To explore the correlation between the parameters of the new generation of Acoustic Cardiography and brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and cardiac function grading in the diagnosis of heart failure. Methods: One hundred and sixty-eight inpatients, who were hospitalized in Department of Cardiology, Haikou People's Hospital from May 2016 to July 2017, were enrolled as heart failure group, including NYHA class Ⅰ(n=29), NYHA class Ⅱ(n=40), NYHA class Ⅲ(n=64), NYHA class Ⅳ (n=35). And eighty-seven patients with normal cardiac function were selected as healthy control group. The data of the two groups were analyzed after the Acoustic Cardiography test, BNP determination and LVEF examination. Results: The differences in QRS duration, electromechanical activation time (EMAT), EMAT%, systolic dysfunction index (SDI), third heart sound (S3) and other indicators among the groups with different levels of cardiac function were statistically significant (P<0.05). The difference in left ventricular systolic time (LVST) between the cardiac function grade Ⅰ and healthy group was not significant (P>0.05), while the differences among the rest groups were significant. There was a positive correlation between QRS duration, EMAT%, SDI, S3 and BNP (t=9.46, 11.38, 12.14, 9.67, respectively, P<0.05); LVST and BNP were negatively correlated (t=-14.27, P<0.05). There was a negative correlation between QRS duration, EMAT%, SDI, S3 and LVEF (t=11.24, -8.764, -2.393, -0.579, respectively, P<0.05). There was a positive correlation between LVST and LVEF (t=23.48, P<0.05). There was a positive correlation between QRS duration, EMAT%, SDI, S3 and cardiac function grading (β=0.003, 0.234, 0.419, 0.352, respectively, P<0.05). There was a negative correlation between LVST and cardiac function grade (β=-0.021, P<0.05). Conclusion: The parameters of the Acoustic Cardiography test (EMAT%, EMAT, SDI, S3 ) are closely related to BNP, LVEF and cardiac function grading, and can be used as assistant indexes for the diagnosis and evaluation of heart failure.
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