Small Molecules for Neural Stem Cell Induction
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Updated: Feb 15, 2026

Enumeration of Neural Stem Cells Using Clonal Assays
Published on: October 4, 2016
Donghui Liu1,2, Nimshitha Pavathuparambil Abdul Manaph2,3, Mohammed Al-Hawwas2
11 Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , Nanjing, China .
Abstract:
Generation of induced pluripotent stem cells (iPSCs) from other somatic cells has provided great hopes for transplantation therapies. However, these cells still cannot be used for clinical application due to the low reprogramming and differentiation efficiency beside the risk of mutagenesis and tumor formation. Compared to iPSCs, induced neural stem cells (iNSCs) are easier to terminally differentiate into neural cells and safe; thus, iNSCs hold more opportunities than iPSCs to treat neural diseases. On the other hand, recent studies have showed that small molecules (SMs) can dramatically improve the efficiency of reprogramming and SMs alone can even convert one kind of somatic cells into another, which is much safer and more effective than transcription factor-based methods. In this study, we provide a review of SMs that are generally used in recent neural stem cell induction studies, and discuss the main mechanisms and pathways of each SM.
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