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Published on: March 15, 2024
A case of molecularly profiled extraneural medulloblastoma metastases in a child
Nahla Ali Mobark1, Musa Al-Harbi1, Othman Mosleh1
1Oncology Department, Cancer Centre, King Fahad Medical City, P.O. Box 59046, Riyadh, 11525, Kingdom of Saudi Arabia.
Background:
Extraneural metastases are relatively rare manifestations of medulloblastoma.
Case Presentation:
We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options.
Conclusion:
To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.
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