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Related Concept Videos

Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Nursing Implementation01:15

Nursing Implementation

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Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Personal Identity01:25

Personal Identity

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Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
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Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
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Related Experiment Video

Updated: Feb 15, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
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Implementing genome-driven personalized cardiology in clinical practice.

Ares Pasipoularides1

  • 1Consulting Professor of Surgery, Emeritus Faculty of Surgery and of Biomedical Engineering, Duke University School of Medicine and Graduate School, Durham, NC 27710, USA.

Journal of Molecular and Cellular Cardiology
|January 19, 2018
PubMed
Summary

Genomics offers personalized cardiology approaches for complex cardiovascular diseases (CVDs), integrating genetic data with clinical insights for tailored prevention and treatment. Future advances promise to further refine these genome-driven strategies for improved patient outcomes.

Keywords:
BiomarkersGenome sequencingGenome-& phenome-wide association studies (GWAS/PheWAS)Genomic decoding of phenotypic diversityHemodynamics & myocardial mechanics phenomePersonalized or precision medicine

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Area of Science:

  • Cardiovascular Genomics
  • Precision Medicine
  • Molecular Cardiology

Background:

  • Complex cardiovascular diseases (CVDs) involve intricate interactions between multiple genomic variants, epigenetics, and environmental factors.
  • Understanding the genomics of CVDs like cardiomyopathies, arrhythmias, and heart failure is challenging due to non-linear genotype-phenotype relationships.
  • Electronic medical/health records (EMRs/EHRs) incorporating genomic data create a powerful network for research and clinical application.

Purpose of the Study:

  • To survey current concepts and breakthroughs in cardiovascular genomics.
  • To highlight the potential of genome-driven personalized cardiology in clinical practice.
  • To discuss the integration of genomics with epigenetics and environmental factors for CVD management.

Main Methods:

  • Leveraging multimodal electronic medical/health records (EMRs/EHRs) with genomic information.
  • Analyzing complex interactions between genetic variants, epigenetics, and environmental risk factors.
  • Utilizing high-throughput genomic technologies for precise diagnosis and treatment.

Main Results:

  • Genomics enables insights into pathogenetic pathways, biomarker-assisted diagnosis, and prognosis stratification for CVDs.
  • Personalized cardiology, complementing traditional guidelines, offers customizable CVD prevention, diagnosis, and management.
  • Emerging therapies include stem cell and gene therapies (e.g., CRISPR-Cas9) and metabolomic-pharmacogenomic modalities.

Conclusions:

  • Genome-driven personalized cardiology provides crucial clinical benefits by targeting causal defects at the molecular and cellular levels.
  • While genotype does not equal phenotype, integrating genomic data with clinical information is essential for effective application.
  • Future genomic advancements, combined with epigenetic and environmental insights, hold the potential to significantly impact CVD eradication and improve human health.