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Updated: Feb 15, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Highly effective and chemically stable surface enhanced Raman scattering substrates with flower-like 3D Ag-Au
Ying Zhang1,2, Chengliang Yang3, Bin Xue4
1State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, 130033, China.
Abstract:
We demonstrated flower-like 3D Ag-Au hetero-nanostructures on an indium tin oxide glass (ITO glass) for surface enhanced Raman scattering (SERS) applications. The flower-like 3D Ag nanostructures were obtained through electrodeposition with liquid crystalline soft template which is simple, controllable and cost effective. The flower-like 3D Ag-Au hetero-nanostructures were further fabricated by galvanic replacement reaction of gold (III) chloride trihydrate (HAuCl4·3H2O) solution and flower-like Ag. The flower-like Ag-Au hetero-nanostructure exhibited stronger SERS effects and better chemical stability compared with flower-like Ag nanostructure. The localized surface plasmon resonance (LSPR) spectra, field emission scanning electron microscope (FESEM) photos and Ag-Au ratios were studied which show that the surface morphology and shape of the flower-like Ag-Au hetero-nanostructure play significant roles in enhancing SERS. The flower-like 3D Ag-Au hetero-nanostructures fabricated by electrodeposition in liquid crystalline template and galvanic replacement reaction are simple, cheap, controllable and chemical stable. It is a good candidate for applications in SERS detection and imaging.
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