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miR-149 in Human Cancer: A Systemic Review

Yunjie He1, Dandan Yu2, Lingping Zhu1

  • 1The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.

Journal of Cancer
|January 19, 2018
PubMed

Insights

MicroRNAs (miRNAs) are small molecules that regulate genes. This review focuses on miR-149, highlighting its crucial roles in cancer development and progression for future research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression post-transcriptionally.
  • miRNAs play significant roles in cancer initiation and progression.
  • Aberrant regulation of miR-149 is observed across various tumor types.

Purpose of the Study:

  • To provide a comprehensive overview of miR-149.
  • To summarize the critical roles of miR-149 in cancer.
  • To establish a foundation for future research on miR-149 in oncology.

Main Methods:

  • Literature review of studies on miR-149 and cancer.
  • Analysis of reported functions and dysregulation of miR-149 in tumorigenesis.
  • Synthesis of current knowledge on miR-149's involvement in various cancers.

Main Results:

  • miR-149 is confirmed to be aberrantly regulated in multiple cancers.
  • miR-149 exhibits critical roles in the complex processes of tumorigenesis and cancer progression.
  • Evidence suggests miR-149 acts as a key regulator in the tumor microenvironment.

Conclusions:

  • miR-149 is a significant microRNA with critical implications in cancer.
  • Understanding miR-149's functions is essential for cancer research.
  • Further investigation into miR-149 is warranted for potential therapeutic strategies.
Keywords:
cancer.miR-149miRNA

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