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Related Experiment Video

Updated: Jun 21, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
07:35

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

Clinical Characteristics and Prognostic Risk Factors in Breast Cancer With Liver Metastasis.

Dandan Yu1, Chengjun Zhu2, Sujin Yang3

  • 1Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China, njmu.edu.cn.

The Breast Journal
|June 20, 2026
PubMed
Summary

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Breast cancer liver metastasis (BCLM) affects 1.3% of patients, with risk factors including young age and specific subtypes. Hepatic resection significantly improves survival for BCLM patients.

Area of Science:

  • Oncology
  • Cancer Metastasis
  • Breast Cancer Research

Background:

  • Liver metastasis is a critical negative prognostic indicator for breast cancer patients.
  • Understanding the development and risk factors of breast cancer liver metastasis (BCLM) is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess the development, risk factors, and prognostic determinants of breast cancer liver metastasis (BCLM).
  • To identify key factors influencing survival in patients with BCLM.

Main Methods:

  • Retrospective analysis of large breast cancer cohorts from SEER (N=560,908) and JSPH (N=294) databases.
  • Multivariate logistic regression to identify BCLM risk factors.
  • Kaplan-Meier curves and Cox regression models to evaluate overall survival (OS).
Keywords:
breast cancerliver metastasismolecular subtypereceptor conversion

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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Published on: November 30, 2016

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A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer
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Published on: December 26, 2016

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

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Main Results:

  • BCLM incidence was 1.3% in the SEER cohort, highest in HR-/HER2+ subtypes (4.4%).
  • Risk factors for BCLM include young age, high grade, other organ metastasis, and HER2-positive or triple-negative subtypes.
  • Hepatic resection significantly improved OS (SEER: 90 vs. 35 months; JSPH: not reached vs. 31.3 months). Molecular subtype changes occurred in 27.5% of JSPH patients.

Conclusions:

  • BCLM occurrence is influenced by age, tumor grade, organ involvement, and molecular subtype.
  • Survival is enhanced in BCLM patients with liver-only metastasis, HER2-positive subtype, or after hepatic resection.
  • Prognostic predictors include metastasis characteristics; receptor conversion necessitates reassessment of therapeutic strategies.