Related Experiment Video
Updated: Feb 15, 2026

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)
Published on: June 12, 2017
Working Memory Updating: Load and Binding
Paola Palladino1, Caterina Artuso1
1a Universita degli Studi di Pavia.
Abstract:
In the present study, we aimed to examine how specific objects are updated in working memory. We compared conditions in which contents or content-context bindings from working memory were both encoded and updated (Experiment 1). In addition, for bindings, we manipulated the memory load (i.e., number of contents) to maintain during updating. Results indicated that memory load did not specifically affect the process; rather, the content-context binding (vs. single contents) was critical in determining the increase in response latencies. Results were replicated even in Experiment 2, in which we manipulated the spatial locations of the to-be-recognized probes. Results showed evidence of a potential dissociation between updating of memory contents-only and content-context bindings. In addition, memory load and spatial coherence between phases and probe recognition did not interact with updating performance. Overall, results were taken as a contribution toward mapping the complex nature of the updating mechanism.
Related Concept Videos
The Equilibrium Binding Constant and Binding Strength
System of Memory
Working Memory
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Conserved Binding Sites
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
Ligand Binding and Linkage

