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Translocations, fusion genes, and acute leukemia

Vaskar Saha1, Bryan D Young1, Paul S Freemont2

  • 1Imperial Cancer Research Fund, Department of Medical Oncology, St Bartholomew's Hospital, London EC1A 6BQ, UK.

Journal of Cellular Biochemistry
|January 19, 2018
PubMed
Summary

Chromosomal translocations in leukemia involve regulatory genes essential for normal blood cell development. Their disruption, particularly involving trithorax and polycomb complexes, leads to leukemia by altering chromatin structure and cell maturation.

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