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Updated: Feb 15, 2026

Use of In Vivo Assembly for High-efficiency Plasmid Construction
Published on: February 7, 2025
Construction of and efficient sampling from the simplicial configuration model
Jean-Gabriel Young1, Giovanni Petri2, Francesco Vaccarino2,3
1Département de Physique, de Génie Physique, et d'Optique, Université Laval, G1V 0A6 Québec (Québec), Canada.
Abstract:
Simplicial complexes are now a popular alternative to networks when it comes to describing the structure of complex systems, primarily because they encode multinode interactions explicitly. With this new description comes the need for principled null models that allow for easy comparison with empirical data. We propose a natural candidate, the simplicial configuration model. The core of our contribution is an efficient and uniform Markov chain Monte Carlo sampler for this model. We demonstrate its usefulness in a short case study by investigating the topology of three real systems and their randomized counterparts (using their Betti numbers). For two out of three systems, the model allows us to reject the hypothesis that there is no organization beyond the local scale.
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