Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleus01:32

The Nucleus

105.6K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
105.6K
The Nucleus01:25

The Nucleus

7.9K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
7.9K
Correlations02:20

Correlations

36.6K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K
Correlation and Causation01:27

Correlation and Causation

43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
Correlation01:09

Correlation

15.2K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.2K
Viral Recombination00:57

Viral Recombination

25.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Resolving fluorescently labeled species using highly multiplexed spectral FLIM.

Scientific reports·2026
Same author

Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium.

bioRxiv : the preprint server for biology·2026
Same author

Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis.

Communications biology·2026
Same author

Targeting secreted PLA<sub>2</sub> interactions with EGFR and vimentin to arrest prostate tumour growth.

Cell death & disease·2025
Same author

ESPRESSO: spatiotemporal omics based on organelle phenotyping.

Nature methods·2025

Related Experiment Video

Updated: Feb 15, 2026

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells
09:18

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells

Published on: September 7, 2018

81.9K

Viral highway to nucleus exposed by image correlation analyses.

Elina Mäntylä1, Jenu V Chacko2,3, Vesa Aho4

  • 1Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland.

Scientific Reports
|January 20, 2018
PubMed
Summary

This study reveals the intricate single-particle dynamics of parvovirus entry into cells. We uncovered novel details about viral capsid movement and interactions during nuclear translocation.

More Related Videos

Viral Nanoparticles for In vivo Tumor Imaging
14:04

Viral Nanoparticles for In vivo Tumor Imaging

Published on: November 16, 2012

17.8K
Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy
06:51

Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy

Published on: August 2, 2018

7.6K

Related Experiment Videos

Last Updated: Feb 15, 2026

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells
09:18

Correlative Light Electron Microscopy CLEM for Tracking and Imaging Viral Protein Associated Structures in Cryo-immobilized Cells

Published on: September 7, 2018

81.9K
Viral Nanoparticles for In vivo Tumor Imaging
14:04

Viral Nanoparticles for In vivo Tumor Imaging

Published on: November 16, 2012

17.8K
Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy
06:51

Confocal Microscopy Reveals Cell Surface Receptor Aggregation Through Image Correlation Spectroscopy

Published on: August 2, 2018

7.6K

Area of Science:

  • Virology
  • Cell Biology
  • Microscopy

Background:

  • Parvovirus genome translocation is a complex process.
  • Capsid proteins mediate viral entry into the nucleus.
  • Understanding viral entry dynamics is crucial for antiviral strategies.

Purpose of the Study:

  • To investigate the single-particle dynamics of parvovirus entry into living cells.
  • To elucidate the multistep process of parvoviral genome translocation.
  • To reveal previously unknown interactions during the viral entry pathway.

Main Methods:

  • Fast confocal microscopy line scan imaging.
  • Image correlation methods (auto-, pair-, cross-correlation).
  • Number and brightness analysis for single-particle tracking.

Main Results:

  • Virus particle movement within endosomes varies from fast to slow.
  • Cytoplasmic capsids exhibit fast transit to the nuclear envelope.
  • Capsids show slow movement in the nucleoplasm, with fragments diffusing rapidly.

Conclusions:

  • The study provides a detailed, single-particle view of parvovirus entry.
  • Novel dynamics of capsid translocation and importin β interactions were identified.
  • This research advances our understanding of viral nuclear import mechanisms.