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The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) R620W Functional Polymorphism in Psoriasis
Ghaleb Bin Huraib1, Fahad Al Harthi1, Misbahul Arfin2
1Department of Dermatology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
|January 20, 2018
Summary
The PTPN22 (1858C/T) gene variant significantly increases psoriasis risk in Saudi individuals. This specific PTPN22 polymorphism may serve as a valuable biomarker for assessing psoriasis susceptibility.
Area of Science:
- Genetics
- Immunology
- Dermatology
Background:
- Psoriasis is an autoimmune condition influenced by genetic and environmental factors.
- The PTPN22 gene polymorphism is linked to psoriasis susceptibility, but data from Middle Eastern populations are lacking.
Purpose of the Study:
- To investigate the association between the PTPN22 (1858C/T) R620W polymorphism and psoriasis in a Saudi cohort.
Main Methods:
- A case-control study involving 306 Saudi subjects (106 psoriasis patients, 200 controls).
- Genotyping of PTPN22 (1858C/T) variants was performed using tetra-primer ARMS-PCR.
- Allele and genotype frequencies were compared between patients and controls.
Main Results:
- The CT genotype of PTPN22 (1858C/T) was more frequent in psoriasis patients (P < .001, RR=7.151).
- The T allele, encoding tryptophan, was significantly increased in psoriasis cases (P < .001, RR=5.76).
- Individuals with the T allele showed higher susceptibility to psoriasis.
Conclusions:
- The PTPN22 (1858C/T) polymorphism is positively associated with psoriasis susceptibility in the Saudi population.
- This PTPN22 variant could be a potential biomarker for evaluating psoriasis risk.
- Further research with larger, diverse populations is recommended.
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