Related Experiment Video
Updated: Feb 15, 2026
11:35
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
58.8K
Improved cognitive performance and event-related potential changes following working memory training in patients with
Thomas J Covey1,2, Janet L Shucard1,2, Ralph Hb Benedict3,2
1Division of Cognitive and Behavioral Neurosciences, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, USA.
Summary
Working memory training using the n-back task improved cognitive function and brain activity in multiple sclerosis (MS) patients. This suggests neural plasticity may enhance cognitive performance in MS.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Rehabilitation Medicine
Background:
- Cognitive deficits are common in multiple sclerosis (MS).
- Working memory is often impaired in MS.
- Few studies have specifically addressed working memory rehabilitation in MS.
Purpose of the Study:
- To investigate the impact of n-back working memory training on cognitive performance in MS patients.
- To assess changes in brain function using event-related potentials (ERPs) after working memory training in MS.
Main Methods:
- 12 MS patients and 12 healthy controls (HC) completed 20 sessions of n-back training.
- Cognitive tests and event-related potential (ERP) measures (N2, P3 components) were administered pre- and post-training.
- A 3-back task was used to elicit cognitive-related potentials.
Main Results:
- Both MS patients and HCs showed significant improvements in working memory, processing speed, attention, and reasoning post-training.
- N-back training led to enhanced N2 ERP component amplitude in both groups.
- Earlier N2 and P3 latencies were observed in MS patients and HCs after training.
Conclusions:
- N-back working memory training can enhance cognitive function in individuals with MS.
- Observed changes in ERPs (N2 amplitude, N2/P3 latency) suggest neural plasticity underlying cognitive improvements in MS.
- Targeted working memory rehabilitation shows promise for managing cognitive impairments in MS.
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