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Updated: Aug 11, 2026
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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
Published on: October 13, 2023
Sex-dependent bioactive lipid mediator profiles in multiple sclerosis
Wing Hee Fung1,2, Serhii Chornyi2, Menno M Schoonheim3
1MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.
Summary
Sex differences in multiple sclerosis (MS) may involve lipid mediators (LMs). Certain LMs like 9-HOTrE show potential neuroprotective effects in MS patients, differing between sexes.
Area of Science:
- Neuroimmunology
- Lipidomics
- Sex Differences in Disease
Background:
- Pathophysiology of sex differences in multiple sclerosis (MS) is not fully understood.
- Bioactive lipid mediators (LMs) are key regulators of neuro-inflammatory responses and potential contributors to MS sex disparities.
Purpose of the Study:
- To investigate sex-dependent differences in lipid mediator profiles in individuals with MS.
- To explore the relationship between specific LMs and clinical outcomes in MS.
Main Methods:
- Plasma lipid profiles were analyzed using targeted HPLC-MS/MS in a cohort of 410 individuals (285 with MS).
- Lipid levels were compared between sexes and correlated with Expanded Disability Status Scale (EDSS), neurofilament light (NfL), whole brain volume (WBV), and T2 lesion volume (LV).
Main Results:
- Sex-specific differences in LM levels were observed in individuals with MS.
- Higher levels of 11,12-DiHET in men correlated with increased disability (EDSS) and neuroaxonal damage (NfL).
- Elevated levels of LMs, including 9-HOTrE, in women were associated with lower EDSS and T2 lesion volume (LV).
Conclusions:
- Findings suggest sex-dependent, lipid-mediated pathophysiological mechanisms in MS.
- Specific LMs, such as 9-HOTrE, may possess neuroprotective properties in the context of MS.
