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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute: Micro-computed
Jung-Seok Lee1, Jae-Kook Cha1, Daniel S Thoma2
1Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.
Objective:
This study of a human autopsy case aimed to characterize the histologic and micro-computed tomographic results of maxillary sinus augmentation using a synthetic bone substitute and simultaneous implant placement at 6 years.
Material And Methods:
This report is based on the whole-body donation of a 62-year-old male patient who died due to bladder cancer. Implants had been placed in conjunction with sinus augmentation using a mixture of biphasic calcium phosphate and autogenous bone into both maxillary sinuses 6 years prior to the body donation. The maxillary sinus areas containing implants were gently removed from the cadaver and scanned using high-resolution micro-computed tomography. Samples were sectioned, prepared for undecalcified histologic slides and stained with haematoxylin-eosin.
Results:
The augmented volume was observed up to the apex of the implants, which were successfully osseointegrated. Cross-sectional micro-computed tomographic views revealed that the bone-substitute particles were embedded in radiopaque-mineralized tissues showing a trabecular pattern around the implants. The histologic analysis revealed mature lamellar bone surrounding the remaining bone-substitute particles as well as well-organized bone marrow spaces in the augment bone area and around the dental implants.
Conclusion:
This human autopsy study histologically confirmed the presence of successful bone formation and long-term volume stability after sinus augmentation using biphasic calcium phosphate and simultaneous implant placement.
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