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Updated: Feb 15, 2026

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Published on: July 1, 2018

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Novel Streptococcus suis Sequence Type 834 among Humans, Madagascar

Mihaja Raberahona, Saïda Rasoanandrasana, Vonintsoa Lalaina Rahajamanana

    Emerging Infectious Diseases
    |January 20, 2018
    PubMed

    Insights

    Two cases of meningitis caused by Streptococcus suis were identified in Madagascar. A novel sequence type (ST-834) carrying virulence markers and a specific mutation was characterized.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Genomics

    Background:

    • Streptococcus suis is a zoonotic pathogen causing meningitis in humans.
    • Madagascar has reported sporadic cases of Streptococcus suis meningitis.

    Observation:

    • Two meningitis cases linked to Streptococcus suis were documented in Madagascar (2015, 2016).
    • Genomic analysis was performed on the causative bacterial isolates.

    Findings:

    • A novel sequence type, designated ST-834, was identified.
    • This novel ST-834 harbored the mrp+, sly+, and epf+ virulence markers.
    • A specific G→T mutation at position 174 was observed, resulting in a mutS1 to mutS284 substitution.

    Implications:

    • Characterization of ST-834 provides insights into Streptococcus suis epidemiology.
    • Understanding virulence markers and mutations aids in assessing meningitis risk.
    • This finding contributes to the surveillance of Streptococcus suis in Madagascar and globally.
    Keywords:
    AfricaMadagascarST834Streptococcus pneumoniaeStreptococcus suisTogobacteriabacterial meningitisfarmhuman infectionmeningitis/encephalitispigpork meatswinewhole-genome sequencing

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