Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Understanding the Self

Understanding the Self

The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...

Understanding Self-Concept

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...

Understanding Deception

Understanding Deception

Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...

Understanding Love

Understanding Love

Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...

Understanding Consciousness

Understanding Consciousness

Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...

Understanding Sleep

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular mechanism of Alzheimer's disease using integrated multi-omics.

Frontiers in aging neuroscience·2026

Same author

Identification of alterations of immunometabolism associated with Pompe disease.

Cellular and molecular life sciences : CMLS·2026

Same author

Cell-Driven Encapsulation of Chlorophyllin-Based Carbon Dots within Exosomes for Enhanced Photodynamic Therapy: miRNA Profiling Reveals Mechanistic Insights.

ACS applied materials & interfaces·2025

Same author

α-synuclein in Parkinson's disease: a central point of convergence with depression.

NPJ Parkinson's disease·2025

Same author

Opposing outcomes of short- and long-term epigenetic therapy in breast cancer: Implications for chemotherapy response.

Biochemical pharmacology·2025

Same author

Nanotherapeutic Strategies for Overcoming the Blood-Brain Barrier: Applications in Disease Modeling and Drug Delivery.

ACS omega·2025

Search research articles

Related Experiment Video

Updated: Feb 15, 2026

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

Cellular reprogramming: A new way to understand aging mechanisms.

Burcu Yener Ilce¹, Umut Cagin², Acelya Yilmazer^3,4

¹Biotechnology Institute, Ankara University, Ankara, Turkey.

Wiley Interdisciplinary Reviews. Developmental Biology

|January 20, 2018

Summary

Induced pluripotent stem cells (iPSCs) offer a novel way to study human aging and diseases. Research into iPSC reprogramming may unlock strategies for rejuvenation and reversing the aging process.

Keywords:

aging cell reprogramming iPSCs

More Related Videos

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Related Experiment Videos

Last Updated: Feb 15, 2026

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Understanding Cerebellar Pattern Formation

Understanding Cerebellar Pattern Formation

Published on: November 1, 2007

Area of Science:

Stem cell biology
Aging research
Regenerative medicine

Background:

Global life expectancy is increasing, leading to a rapidly growing elderly population.
Understanding the mechanisms of human aging and age-related diseases is a critical challenge.
Traditional model organisms have limitations in studying human-specific aging processes.

Purpose of the Study:

To explore the utility of induced pluripotent stem cells (iPSCs) as a model for human aging.
To discuss the potential of somatic cell reprogramming for developing rejuvenation strategies.
To critically review existing research on the interplay between aging and cell reprogramming.

Main Methods:

Review and discussion of scientific literature on iPSCs and aging.
Analysis of reprogramming technology for somatic cells.
Evaluation of iPSCs as an alternative to traditional model organisms.

Main Results:

iPSCs provide a valuable platform for studying human aging and associated diseases.
Somatic cell reprogramming holds promise for future rejuvenation strategies.
The relationship between aging and cell reprogramming efficiency requires further investigation.

Conclusions:

iPSCs are a powerful tool for aging research, offering insights beyond traditional models.
Further quantitative studies are needed to fully understand how aging impacts human cell reprogramming.
This research opens avenues for preventing or reversing the aging process.