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Diagnosis and Management of Hepatitis C Infection in Primary Care Settings
Debra Guss1, Jagannath Sherigar2, Paul Rosen3
1Division of Gastroenterology and Hepatobiliary Diseases, New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, USA. Dag9132@nyp.org.
Insights
Hepatitis C virus (HCV) treatments are now over 90% effective with few side effects, simplifying management. Primary care physicians can lead in diagnosing and treating HCV infection, marking a new era in patient care.
Area of Science:
- Hepatology
- Infectious Diseases
- Primary Care Medicine
Background:
- Hepatitis C virus (HCV) infection is a major global health concern.
- It is a leading cause of cirrhosis, liver cancer, and liver transplants in the US.
- Recent advancements have transformed HCV management.
Purpose of the Study:
- To provide a comprehensive overview of HCV management.
- To guide primary care physicians in diagnosing and treating HCV.
- To discuss factors influencing treatment decisions.
Main Methods:
- This review synthesizes current knowledge on HCV.
- It covers acute vs. chronic infection, transmission, testing, diagnosis, and treatment.
- It considers patient and medication factors affecting treatment choice.
Main Results:
- Current HCV medications exceed 90% efficacy.
- Treatments have a high barrier to resistance and minimal side effects.
- Management has become simpler and more effective.
Conclusions:
- A new era in HCV management has arrived.
- Primary care physicians can play a pivotal role in HCV care.
- Integrated primary care and hepatology approaches enhance patient outcomes.
Abstract:
Hepatitis C virus (HCV) infection is a significant health problem worldwide, and is the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation in the United States. The management of HCV has changed significantly over the last 5 years, as treatments have become simpler and more efficacious. Medication efficacy is now greater than 90%, with a high barrier to resistance and few side effects. This review is a collaboration between primary care and hepatology providers to explore all aspects of HCV management: acute versus chronic HCV infection, transmission and testing, and diagnosis and treatment. Specific medications for the treatment of HCV infection are considered, and patient and medication factors including genotype, liver disease status, and comorbidities affecting medication choice are discussed. This is a new era for the management of HCV infection, and interested primary care physicians, family doctors, and general internists can be at the forefront of diagnosis, management, and treatment of HCV.
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