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Hyperconnective and hypoconnective cortical and subcortical functional networks in multiple system atrophy.

Johannes Rosskopf1, Martin Gorges1, Hans-Peter Müller1

  • 1Department of Neurology, University of Ulm, Ulm, Germany.

Parkinsonism & Related Disorders
|January 21, 2018
PubMed
Summary

Multiple system atrophy (MSA) shows altered brain connectivity, with higher ponto-cerebellar and lower default mode network function. These changes correlate with impaired smooth pursuit eye movements in patients.

Keywords:
Atypical parkinsonian syndromeIntrinsic functional connectivityMagnetic resonance imagingMultiple system atrophyResting-state

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Area of Science:

  • Neuroscience
  • Neurology
  • Functional Neuroimaging

Background:

  • Multiple system atrophy (MSA) is a neurodegenerative disease.
  • The functional brain connectivity in MSA is not well understood.
  • Investigating brain network alterations and their clinical links is crucial for understanding MSA.

Purpose of the Study:

  • To investigate functional brain connectivity in the cortex and subcortical networks in MSA patients.
  • To explore the relationship between altered functional connectivity and clinical symptoms in MSA.
  • To understand the network-based mechanisms underlying MSA.

Main Methods:

  • Resting-state functional MRI (fMRI) data were acquired from 22 MSA patients and 22 healthy controls.
  • Clinical assessments and video-oculographic recordings were performed.
  • Whole-brain functional connectivity analysis was conducted.

Main Results:

  • MSA patients exhibited increased ponto-cerebellar functional connectivity and decreased default mode network connectivity compared to controls.
  • No significant differences in motor or control network connectivity were found.
  • Increased ponto-cerebellar connectivity correlated with more severe smooth pursuit impairment.

Conclusions:

  • Functional connectivity in MSA involves a combination of hyperconnectivity and hypoconnectivity.
  • These patterns may reflect adaptive compensatory mechanisms and disconnection syndromes.
  • Altered ponto-cerebellar connectivity is linked to oculomotor deficits in MSA.