Related Experiment Video
Updated: Feb 15, 2026
Functional Calcium Imaging in Developing Cortical Networks
Published on: October 22, 2011
Hyperconnective and hypoconnective cortical and subcortical functional networks in multiple system atrophy
Johannes Rosskopf1, Martin Gorges1, Hans-Peter Müller1
1Department of Neurology, University of Ulm, Ulm, Germany.
Introduction:
In multiple system atrophy (MSA), the organization of the functional brain connectivity within cortical and subcortical networks and its clinical correlates remains to be investigated.
Methods:
Whole-brain based 'resting-state' fMRI data were obtained from 22 MSA patients (11 MSA-C, 11 MSA-P) and 22 matched healthy controls, together with standardized clinical assessment and video-oculographic recordings (EyeLink®).
Results:
MSA patients vs. controls showed significantly higher ponto-cerebellar functional connectivity and lower default mode network connectivity (p < .05, corrected). No differences were observed in the motor network and in the control network. The higher the ponto-cerebellar network functional connectivity was, the more pronounced was smooth pursuit impairment.
Conclusion:
This functional connectivity analysis supports a network-dependent combination of hyper- and hypoconnectivity states in MSA, in agreement with adaptive compensatory responses (hyperconnectivity) and a function disconnection syndrome (hypoconnectivity) that may occur in a consecutive sequence.
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