Combining chemotherapy with PD-1 blockade in NSCLC.
Matthen Mathew1, Thomas Enzler1, Catherine A Shu1
1Columbia University Medical Center, 177 Fort Washington Avenue, MHB 6GN-435, New York, NY 10032, United States.
Pharmacology & Therapeutics
|January 22, 2018
Summary
Combining chemotherapy with PD-1 blockade shows promise for treating advanced non-small cell lung cancer (NSCLC). This approach enhances antitumor immunity and offers a potential new frontline strategy for patients.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Antitumor immunity involves T-cell mediated elimination of tumor cells via tumor-specific antigens.
- Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis show efficacy in non-small cell lung cancer (NSCLC).
- A significant need exists for improved frontline treatments for advanced NSCLC.
Purpose of the Study:
- To review the preclinical rationale for combining chemotherapy with PD-1 blockade in NSCLC.
- To summarize recent clinical trial data on the efficacy of this combination therapy.
Main Methods:
- Review of preclinical studies investigating the synergistic effects of chemotherapy and PD-1 inhibitors.
- Analysis of published clinical trial data evaluating combination therapy in NSCLC patients.
Main Results:
- Chemotherapy can enhance tumor antigenicity through immunogenic cell death (ICD).
- Chemotherapy can reduce immunosuppression within the tumor microenvironment (TME).
- Combining chemotherapy with PD-1 blockade has yielded encouraging results in frontline NSCLC treatment.
Conclusions:
- The combination of chemotherapy and PD-1 blockade presents a promising synergistic approach for advanced NSCLC.
- This combination strategy warrants further investigation as a potential frontline treatment for NSCLC patients.
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