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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
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Glucose-sensitive polyelectrolyte microcapsules based on (alginate/chitosan) pair.

Sabrina Belbekhouche1, Saddam Charaabi1, Luc Picton2

  • 1Université Paris Est, ICMPE (UMR7182), CNRS, UPEC, F-94320 Thiais, France.

Carbohydrate Polymers
|January 22, 2018
PubMed
Summary

Novel glucose-responsive multilayer assemblies were created using layer-by-layer deposition. Crosslinking these polysaccharide assemblies enhances stability and enables controlled release, offering potential for smart drug delivery systems.

Keywords:
CapsuleGlucose-responsiveLayer-by-layerPhenylboronic acid chemistryPolysaccharides

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Developing advanced materials with tunable properties is crucial for applications like controlled release.
  • Stimuli-responsive polymers offer unique functionalities based on environmental changes.
  • Polysaccharide-based assemblies present biocompatible and versatile platforms.

Purpose of the Study:

  • To create novel chemical stimulus-responsive multilayer assemblies using layer-by-layer deposition.
  • To investigate glucose responsiveness through chemical modification of alginate.
  • To develop stable, smart microcapsules for potential controlled release applications.

Main Methods:

  • Layer-by-layer (LbL) deposition of oppositely charged polysaccharides (alginate derivative and chitosan).
  • Chemical modification of alginate with phenylboronic acid moieties for glucose sensitivity.
  • Quartz Crystal Microbalance (QCM) measurements for assembly analysis.
  • Glutaraldehyde-mediated crosslinking for enhanced stability.
  • Fabrication of microcapsules using dissolvable CaCO3 templates.

Main Results:

  • Successful fabrication of glucose-responsive multilayer assemblies on flat and spherical surfaces.
  • Demonstrated concentration-dependent glucose-induced swelling of the polysaccharide assemblies.
  • Crosslinked assemblies exhibited improved pH stability (pH 4-9) and glucose-responsive swelling.
  • Developed smart microcapsules with stable shells and controlled permeability.
  • Crosslinking prevented capsule dissolution and enabled tunable release of entrapped molecules.

Conclusions:

  • LbL deposition is effective for creating stimuli-responsive polysaccharide multilayer assemblies.
  • Chemical modification and crosslinking provide tunable stability and responsiveness.
  • The developed smart microcapsules show promise for controlled release applications.