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Updated: Feb 15, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Targeting Candida spp. to develop antifungal agents
Tânia P Salci1, Melyssa Negri2, Ana K R Abadio3
1Universidade Estadual de Maringá, Av. Colombo, 5.790 - Jd. Universitário, CEP 87020-900 Maringá, Paraná, Brazil; Centro Universitário Integrado, Rodovia BR 158, Km 207, CEP 87300-970 Campo Mourão, Paraná, Brazil.
Abstract:
Invasive fungal infections are a complex challenge throughout the world because of their high incidence, mainly in critically ill patients, and high mortality rates. The antifungal agents currently available are limited; thus, there is a need for the rapid development of new drugs. In silico methods are a modern strategy to explore interactions between new compounds and specific fungal targets, but they depend on precise genetic information. Here, we discuss the main Candida spp. target genes, including information about null mutants, virulence, cytolocalization, co-regulatory genes, and compounds that are related to protein expression. These data will provide a basis for the future in silico development of antifungal drugs.
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