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Application of Chimera grid to modelling cell motion and aggregation in a narrow tube
B Chung1, P C Johnson2, A S Popel1
1Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Abstract:
A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.
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