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Published on: September 8, 2023
Treatment Outcomes with Selective Coil Embolization for Large or Giant Aneurysms : Prognostic Implications of
Kyung Il Jo1,2, Na-Rae Yang3, Pyoung Jeon1
1Departments of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Insights
Coil embolization for large aneurysms showed reasonable safety but continuous long-term risks of recanalization and thromboembolism, particularly with incomplete occlusion. Careful follow-up is crucial for patients with incomplete aneurysm occlusion.
Area of Science:
- Neurosurgery
- Interventional Radiology
- Vascular Neurology
Background:
- Large or giant aneurysms pose significant risks.
- Endovascular coil embolization is a treatment option.
- Long-term outcomes require thorough evaluation.
Purpose of the Study:
- To assess the immediate and long-term efficacy of coil embolization for large/giant aneurysms.
- To evaluate the safety profile of this endovascular procedure.
- To identify factors influencing recurrence and thromboembolic events.
Main Methods:
- Retrospective review of 150 cases of large/giant aneurysms treated with coil embolization.
- Analysis of medical records and imaging findings.
- Statistical evaluation for prognostic factors of recurrence and delayed thromboembolism.
Main Results:
- Procedure-related symptomatic complications occurred in 3.3% of patients.
- The annual recurrence rate was 4.6% per year.
- Incomplete occlusion was the sole factor associated with recurrence (p=0.008) and delayed infarction.
Conclusions:
- Coil embolization offers reasonable immediate safety but carries continuous long-term risks.
- Incomplete occlusion is linked to recurrence and delayed thromboembolic complications.
- Close patient monitoring is essential for incomplete occlusions to detect delayed events.
Objective:
The objectives of this study were to evaluate the immediate and long-term efficacy and safety of coil embolization for large or giant aneurysms.
Methods:
One hundred and fifty large or giant aneurysm cases treated with endovascular coil embolization between January 2005 and February 2014 at a single institute were included in this study. Medical records and imaging findings were reviewed. Statistical analysis was performed to evaluate prognostic factors associated with major recurrence (major recanalization or rupture) and delayed thromboembolism after selective coil embolization.
Results:
Procedure-related symptomatic complications occurred in five (3.3%) patients. The mean clinical and radiological follow-up periods were 38 months (range, 2-110) and 26 months (range, 6-108), respectively. During the follow-up period, the estimated recurrence rate was 4.6% per year. Multivariate analysis using Cox regression showed the degree of occlusion to be the only factor associated with recurrence (p=0.008, hazard ratio 3.15, 95% confidence interval 1.34-7.41). The patient's history of rupture in addition to the size and location of the aneurysm were not associated with recurrence in this study. Delayed infarction occurred in eight cases, and all were incompletely occluded.
Conclusion:
Although immediate postprocedural safety profiles were reasonable, longterm results showed recanalization and thromboembolic events to occur continuously, especially in patients with incomplete occlusion. In addition, incomplete occlusion was associated with delayed thromboembolic complications. Patients with incomplete occlusions should be followed carefully for delayed recurrence or delayed thromboembolic events.
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