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A role for CA3 in social recognition memory.

Ming-Ching Chiang1, Arthur J Y Huang2, Marie E Wintzer2

  • 1Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan; Laboratory for Molecular Brain Science, Department of Life Sciences and Biomedical Science, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan.

Behavioural Brain Research
|January 23, 2018
PubMed
Summary

Hippocampal CA3 pyramidal cell plasticity is essential for social recognition memory. Deleting the NMDA receptor subunit 1 (NR1) gene in CA3, but not DG, impaired social memory, highlighting CA3

Keywords:
CA3HippocampusSocial memorySynaptic plasticity

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Molecular Biology

Background:

  • Social recognition memory is vital for survival, enabling identification of conspecifics, mates, and enemies.
  • The hippocampus is implicated in human social and episodic memory, but rodent social memory circuit mechanisms are under active investigation.
  • Previous studies identified roles for dorsal CA2 and ventral CA1 in mouse social memory, yet comprehensive comparative analyses are lacking.

Purpose of the Study:

  • To investigate the differential contributions of hippocampal subfields to social memory using conditional genetics.
  • To elucidate the specific roles of CA3 pyramidal cell plasticity and activity in social memory encoding.

Main Methods:

  • Conditional genetic deletion of the NMDA receptor subunit 1 (NR1) gene in specific hippocampal subfields (CA3 and DG).
  • Conditional pharmacogenetic inhibition of CA3 neuronal activity.
  • Assessment of social memory performance in mice.

Main Results:

  • Deletion of NR1 in CA3 pyramidal cells, disrupting synaptic plasticity, led to significant social memory deficits.
  • Deletion of NR1 in DG granule cells did not affect social memory performance.
  • Pharmacogenetic inhibition revealed that ventral CA3 activity, but not dorsal CA3, is critical for social memory encoding.

Conclusions:

  • CA3 pyramidal cell plasticity and transmission are crucial for encoding social stimuli.
  • Ventral CA3 activity plays a necessary role in the formation of social memories.
  • These findings contribute to a more detailed understanding of the hippocampal circuits underlying social memory.