Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to "Polycation-Carbon Nanohybrids with Superior Rough Hollow Morphology for the NIR-II Responsive Multimodal Therapy".

ACS applied materials & interfaces·2026

Same author

A multimodal deep learning model predicting hyperprogressive disease for PD-1 blockade in advanced hepatocellular carcinoma.

NPJ digital medicine·2026

Same author

APOE ε4 Allele is Associated with Cognitive Impairment in Chinese Sporadic ALS: A Retrospective Cohort Study.

Biomedical and environmental sciences : BES·2026

Same author

A Dual-Functioning Embolic Microsphere Platform for Combined Antiangiogenic and Anti-Inflammatory Therapy for Rheumatoid Arthritis.

ACS omega·2026

Same author

Diagnostic value of subtraction CT in evaluating the efficacy of transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients compared to conventional CT and MRI.

Quantitative imaging in medicine and surgery·2026

Same author

Ablation of pulmonary oligometastasis in advanced hepatocellular carcinoma treated with Lenvatinib: a retrospective multicenter study.

Therapeutic advances in medical oncology·2026

Same journal

Pathology-Informed Augmentation Improves Cross-Cohort IMU-to-vGRF Estimation Between Healthy Adults and Adults With Osteoarthritis.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same journal

Effects of task-driven head orientations on gait and balance during walking in virtual reality.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same journal

Wearable sensor-based Mild Cognitive Impairment Identification: A Multi-Domain Gait Analysis Approach with Association Rule Mining.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same journal

Semi-implantable Micro-cooler for Dorsal Root Ganglion Enables Targeted, Sustained, and Cumulative Pain Relief.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same journal

Auditory Cue Integration for a Power-Assisted Gait Training System Based on Neurodevelopmental Treatment Principles.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

Same journal

Quantifying the dynamics that link leg tendon vibration to induced periodic postural oscillations in young subjects Differential effects of light touch on the induced sway.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Closed-Loop Optogenetic Temperature Control System for Inducing Mild Hypothermia in Rats.

Sining Li, Zhihao Ru, Kai Zhang

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society

|April 21, 2026

Summary

This summary is machine-generated.

Optogenetic stimulation of the medial preoptic area (MPA) in rats effectively lowered core body temperature. This novel closed-loop system allows for controlled induction, maintenance, and rewarming, advancing targeted temperature management strategies.

More Related Videos

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Related Experiment Videos

Last Updated: Apr 23, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Area of Science:

Neuroscience
Thermoregulation
Optogenetics

Background:

Mild hypothermia offers neuroprotection but conventional cooling triggers stress responses.
Neuromodulation presents an alternative to overcome limitations of physical cooling methods.
The medial preoptic area (MPA) is crucial for thermoregulation and contains temperature-sensitive neurons.

Purpose of the Study:

To investigate optogenetic stimulation in the MPA for inducing and controlling hypothermia.
To develop a closed-loop system for precise temperature management using step function opsins (SSFOs).

Main Methods:

Optogenetic stimulation of SSFOs in the rat MPA using blue light (465 nm).
Development of a closed-loop system utilizing blue light activation and yellow light (589 nm) for SSFO deactivation.
Monitoring core body temperature changes over a 180-minute period in awake rats.

Main Results:

Optogenetic stimulation induced a mean temperature reduction of -2.48 ± 0.40°C.
Optogenetic methods showed higher survival rates and more stable temperature control compared to chemogenetics.
The closed-loop system successfully enabled controlled induction, maintenance, and rewarming of hypothermia.

Conclusions:

Optogenetic neuromodulation of the MPA is a viable strategy for inducing and controlling hypothermia.
The developed closed-loop system offers precise control over temperature regulation, including rewarming.
This platform facilitates further research into targeted temperature management for neuroprotection.