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The full-length sequence of the HLA-C allele, HLA-C*03:40:01

L Li1, Z Li1, H-Y Zou1

  • 1Immunogenetic Laboratory, Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, China.

HLA
|January 23, 2018
PubMed

Insights

Researchers confirmed the complete genetic sequence of HLA-C*03:40:01. This Human Leukocyte Antigen (HLA) sequence was determined using cloning and sequencing methods in a Chinese donor sample.

Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
  • Accurate HLA typing is essential for transplantation and disease association studies.

Purpose of the Study:

  • To confirm the full-length nucleotide sequence of the HLA-C*03:40:01 allele.
  • To provide a reference sequence for this specific HLA allele.

Main Methods:

  • Cloning of the HLA-C*03:40:01 gene.
  • Sanger sequencing to determine the nucleotide sequence.

Main Results:

  • The complete full-length sequence of HLA-C*03:40:01 was successfully confirmed.
  • Sequence data was obtained from a Chinese donor.

Conclusions:

  • The confirmed sequence of HLA-C*03:40:01 provides a valuable resource for immunogenetic research.
  • This finding contributes to the understanding of HLA polymorphism in the Chinese population.

Keywords:
HLAcloning and sequencingfull-length sequence

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