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Updated: Feb 15, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Nonmetastatic Castration-resistant Prostate Cancer: A Modern Perspective

Madeline Cancian1, Joseph F Renzulli2

  • 1Department of Urology, Warren Alpert Medical School, Brown University, Providence, RI.

Urology
|January 23, 2018
PubMed

Insights

New imaging techniques improve diagnosis for nonmetastatic castration-resistant prostate cancer (nmCRPC). Ongoing trials explore novel therapies, including second-generation antiandrogens, offering a promising new treatment paradigm for nmCRPC.

Area of Science:

  • Urology
  • Oncology
  • Radiology

Background:

  • Nonmetastastic castration-resistant prostate cancer (nmCRPC) lacks FDA-approved therapies.
  • Accurate diagnosis and staging are critical for effective treatment planning in nmCRPC.

Purpose of the Study:

  • To review advancements in imaging for nmCRPC.
  • To discuss the rationale for novel therapeutic strategies in nmCRPC.

Main Methods:

  • Review of current literature on advanced imaging techniques.
  • Analysis of ongoing clinical trials for nmCRPC treatments.

Main Results:

  • Novel imaging modalities like fluciclovine PET-CT and Ga-PSMA PET-CT enhance diagnostic accuracy.
  • Three clinical trials are investigating second-generation antiandrogens for nmCRPC.

Conclusions:

  • Improved imaging facilitates precise therapeutic targeting in nmCRPC.
  • Emerging therapies, particularly second-generation antiandrogens, represent a potential paradigm shift in nmCRPC management.

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