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Updated: Feb 15, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
Suvitha Subramaniam1,2, Christoph D Schmid1,2,3, Xue Li Guan4
1Swiss Tropical and Public Health Institute, Basel, Switzerland.
Abstract:
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.
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