"NO" to Autophagy: Fat Does the Trick for Diabetes

The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification.

Science signaling·2026

Inhalation exposure to airborne PM2.5 attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.

American journal of physiology. Cell physiology·2024

ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis.

Proceedings of the National Academy of Sciences of the United States of America·2024

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.

Nature communications·2024

Environmental PM2.5-triggered stress responses in digestive diseases.

eGastroenterology·2024

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.

Circulation·2024

Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion.

Diabetes·2026

Accelerated Brain Aging in Type 1 Diabetes Across Painful and Painless Peripheral Neuropathy: MRI-Based Brain Age Estimates From Deep Learning.

Diabetes·2026

Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity.

Diabetes·2026

Metabolomics-Defined Subtypes of Prediabetes and Risk of Cardiovascular-Kidney-Metabolic Outcomes.

Diabetes·2026

Vascular Regenerative Cell Flux in Diabetes: Mechanistic and Clinical Implications.

Diabetes·2026

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions.

Diabetes·2026

Upper common bile duct neuroendocrine tumor presenting with obstructive jaundice: a case report and literature review.

Frontiers in oncology·2026

Caenorhabditis elegans H1 histone variant HIL-2 is positively regulated by nutrient availability and insulin/IGF signaling but does not affect development.

microPublication biology·2026

A systematic review investigating the safety and efficacy of intravenous iron in people with ND-CKD who are iron deficient but not anaemic.

Clinical kidney journal·2026

Clostridioides difficile osteomyelitis presenting as a Brodie's abscess of the tibia.

BMJ case reports·2026

Believe Your Patient Who Denies Alcohol Dependence/Celiac Disease as a Cause of Wernicke Encephalopathy.

ACG case reports journal·2026

Serum uric acid and TG/HDL-C ratio in non-obese working women: an exploratory cross-sectional study.

BMC endocrine disorders·2026

Related Experiment Videos

"NO" to Autophagy: Fat Does the Trick for Diabetes

Related Concept Videos

The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification.

Inhalation exposure to airborne PM2.5 attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.

ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis.

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.

Environmental PM2.5-triggered stress responses in digestive diseases.

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.

Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion.

Accelerated Brain Aging in Type 1 Diabetes Across Painful and Painless Peripheral Neuropathy: MRI-Based Brain Age Estimates From Deep Learning.

Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity.

Metabolomics-Defined Subtypes of Prediabetes and Risk of Cardiovascular-Kidney-Metabolic Outcomes.

Vascular Regenerative Cell Flux in Diabetes: Mechanistic and Clinical Implications.

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions.

Upper common bile duct neuroendocrine tumor presenting with obstructive jaundice: a case report and literature review.

Caenorhabditis elegans H1 histone variant HIL-2 is positively regulated by nutrient availability and insulin/IGF signaling but does not affect development.

A systematic review investigating the safety and efficacy of intravenous iron in people with ND-CKD who are iron deficient but not anaemic.

Clostridioides difficile osteomyelitis presenting as a Brodie's abscess of the tibia.

Believe Your Patient Who Denies Alcohol Dependence/Celiac Disease as a Cause of Wernicke Encephalopathy.

Serum uric acid and TG/HDL-C ratio in non-obese working women: an exploratory cross-sectional study.

Related Experiment Videos

"NO" to Autophagy: Fat Does the Trick for Diabetes

Related Concept Videos

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