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Updated: Jul 16, 2026
Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy
Published on: May 28, 2021
Caenorhabditis elegans H1 histone variant HIL-2 is positively regulated by nutrient availability and insulin/IGF
1Department of Biology, Duke University, Durham, NC, United States.
Abstract:
Nutrient availability profoundly influences development, and dynamic reorganization of chromatin structure contributes to nutrient-dependent gene regulation. In Caenorhabditis elegans , the insulin/IGF-1 signaling (IIS) pathway regulates gene expression to mediate developmental and metabolic responses to nutrient availability. Here, we characterize regulation and function of H1 histone HIL-2 . HIL-2 expression is high in fed larvae and decreases with reduced food availability and decreased IIS activity. We find that hil-2 does not affect larval development, though hil-2 ( ok2548 ) displays a larval arrest phenotype. Together with work on another H1 variant, HIL-1 , these results suggest that histone H1 variant dynamics contribute to nutrient-dependent gene regulation.
