Related Experiment Video
Updated: Feb 15, 2026
07:42
A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
553
Multiple Organ Dysfunction: The Defining Syndrome of Sepsis
Markus T Ziesmann1, John C Marshall1
1Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto , Toronto, Ontario, Canada .
Surgical Infections
|January 24, 2018
Summary
Sepsis is a severe systemic response to infection, characterized by organ dysfunction. Understanding its manifestations, epidemiology, and pathophysiology is crucial for critical care.
Area of Science:
- Critical care medicine
- Infectious disease
- Immunology
Background:
- Sepsis, a concept recognized since antiquity, is now understood as a severe systemic response to infection.
- It is characterized by acute, life-threatening, yet potentially reversible organ dysfunction.
- Unresolved organ dysfunction is a primary cause of mortality in critical illness.
Purpose of the Study:
- To describe the clinical manifestations of six prototypic organ system dysfunctions in severe sepsis.
- To review the epidemiology of these dysfunctions.
- To discuss the suspected pathophysiology underlying severe sepsis organ dysfunction.
Main Methods:
- Clinical description of organ system dysfunction syndromes.
- Epidemiological data review.
- Pathophysiological analysis.
Main Results:
- Detailed descriptions of six prototypic organ system dysfunction syndromes in severe sepsis.
- Associated epidemiological data presented.
- Suspected pathophysiological mechanisms outlined.
Conclusions:
- Severe sepsis involves distinct organ system dysfunctions with specific clinical presentations.
- Epidemiology and pathophysiology of these dysfunctions are critical areas of study.
- Understanding these elements is key to managing critical illness.
Related Concept Videos
01:24Defining Psychology
8.0K
Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...
8.0K
01:28Piecewise-Defined Functions
330
Piecewise defined functions are mathematical models where different expressions define a function over distinct intervals of the domain. These functions are useful for representing systems with varying behaviors depending on input values.For example, the function: uses a linear rule for inputs less than or equal to –1 and a quadratic rule for values greater than –1. Although it has two formulas, it still defines a single function.Another common type is the absolute value...
330
01:09Defining Social Psychology
509
Social psychology investigates how the presence and actions of others influence individual behavior, cognition, and emotion. Examining the social environment's impact provides a scientific framework for understanding how individuals perceive others and are, in turn, influenced by them. This field seeks to uncover the underlying principles guiding social interactions, exploring phenomena such as conformity, obedience, and prosocial behavior.Core Themes in Social PsychologyOne central focus of...
509
01:29Rules for Defining Functions
385
A relation is a function if each input x is associated with exactly one output y. For example, the equation y = 2x + 5 defines a function because every value of x yields a unique y. However, x = y² + 1 is not a function of x, since a single x-value, such as x = 2, corresponds to two possible y-values: y = 1 and y = -1.The vertical line test helps determine whether a graph represents a function. If a vertical line intersects a curve more than once, the curve fails...
385
01:49Multiple Allele Traits
38.3K
The Concept of Multiple Allelism
38.3K
01:09Levels of Organization
141.9K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
141.9K