Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation...

Area of Science:

• Agricultural Chemistry
• Nanotechnology
• Pesticide Formulation

Background:

• Poorly water-soluble and photosensitive pesticides pose formulation challenges for effective, solvent-free delivery.
• Conventional pesticide formulations often struggle with efficacy, stability, and environmental concerns.

Purpose of the Study:

• To develop a stable, solvent-free solid nanodispersion of avermectin with enhanced efficacy.
• To evaluate the physicochemical properties, anti-photolysis performance, and biological activity of the novel nanodispersion.

Main Methods:

• Microprecipitation and lyophilisation techniques were employed to create the avermectin solid nanodispersion.
• Characterization included particle size analysis, suspensibility, wetting time, and anti-photolysis testing.
• Biological activity was assessed against diamondback moths using LC50 as the evaluation index.

Main Results:

• Avermetcin solid nanodispersion achieved a mean particle size of 188 nm with 99.8% suspensibility and 13 s wetting time.
• The nanoformulation exhibited twice the anti-photolysis performance of the technical material.
• Biological activity was over 1.5 times higher than conventional formulations against diamondback moths.

Conclusions:

• Microprecipitation combined with lyophilisation offers a promising method for creating solvent-free nanoformulations for challenging pesticides.
• The developed solid nanodispersion demonstrates superior performance, reduced surfactant content, and potential for decreased chemical residues and environmental pollution in agriculture.