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Updated: Feb 15, 2026

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
Published on: September 14, 2012
Pediatric nevoid basal cell carcinoma syndrome
Stacey Pilkington1, Lana H McKinley2, Richard A Miller2
1Azeal Dermatology Institute, Boulder, Colorado, USA.
Abstract:
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare, autosomal-dominant, cancer-predisposing, multisystem disorder. The clinical manifestations of NBCCS include multiple basal cell carcinomas (BCCs), odontogenic keratocysts, palmar or plantar pits, and calcification of the falx cerebri. We present a case of an 11-year-old boy with Fitzpatrick skin type V who presented with multiple facial lesions and a history of maxillary keratocysts. Skin biopsy was consistent with pigmented BCC of the right nasolabial fold. Further clinical workup revealed multiple pigmented BCCs, palmoplantar pits, and calcification of the tentorium. Genetic testing revealed a heterozygous mutation in the patched 1 gene, PTCH1, consistent with NBCCS. This case highlights the treatment considerations in pediatric cases of NBCCS in Fitzpatrick skin type V patients.
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