Gender-Specific Differences in All-Cause Mortality Between Incomplete and Complete Revascularization in Patients With...

Area of Science:

• Cardiology
• Interventional Cardiology
• Clinical Research

Background:

• Revascularization strategies for ST-elevation myocardial infarction (STEMI) remain debated.
• The impact of gender on revascularization outcomes in STEMI patients is not fully understood.

Purpose of the Study:

• To investigate gender-specific differences in all-cause mortality between incomplete and complete revascularization in STEMI patients with multi-vessel coronary artery disease.
• To analyze short-term (30-day) and long-term (5-year) mortality outcomes.

Main Methods:

• Retrospective analysis of 375 men and 115 women with first STEMI and multi-vessel coronary artery disease.
• Patients were categorized by gender and revascularization strategy (incomplete vs. complete).
• 30-day and 5-year all-cause mortality were assessed, with adjustments for baseline and angiographic factors.

Main Results:

• No significant gender-strategy interaction for 30-day mortality after STEMI.
• Incomplete revascularization was associated with higher 30-day mortality in both men and women compared to complete revascularization.
• Among 30-day survivors, incomplete revascularization independently predicted 5-year all-cause mortality in men (HR 3.07) but not in women (HR 0.60).

Conclusions:

• Short-term mortality (30-day) following STEMI is not influenced by gender-specific revascularization strategies.
• Incomplete revascularization poses a significant long-term mortality risk for male STEMI survivors.
• Women with STEMI may have different long-term prognoses regarding revascularization strategy compared to men.