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[Kinetics of immune complex priming for hapten- and carrier-specific antibody production]
In guinea pigs primed by injection of bovine gammaglobulin (BGG) anti-BGG immune complexes (IC) prepared in antibody excess, in Freund's complete adjuvant, the effect of this treatment on the immune response induced at various days after IC priming and by injection of DNP-BGG has been investigated. The IC injection did not result in a generation of measurable anti-BGG antibodies but it led to a BGG-specific priming and sensitization. The latter was already there after 5 days, showed its maximum on day 9 and remained for two month. Priming for sub-class-specific anti-carrier and anti-hapten antibody synthesis revealed a different kinetics. While the enhancing mechanims for IgG2 antibody production had their optimum already after 9 days, the same phenomenon for the IgG1 response could be recognized much later (17th day for anti-BGG IgG1, 60th day for anti-DNP IgG1).
In guinea pigs primed by injection of bovine gammaglobulin (BGG) anti-BGG immune complexes (IC) prepared in antibody excess, in Freund's complete adjuvant, the effect of this treatment on the immune response induced at various days after IC priming and by injection of DNP-BGG has been investigated. The IC injection did not result in a generation of measurable anti-BGG antibodies but it led to a BGG-specific priming and sensitization. The latter was already there after 5 days, showed its maximum on day 9 and remained for two month. Priming for sub-class-specific anti-carrier and anti-hapten antibody synthesis revealed a different kinetics. While the enhancing mechanims for IgG2 antibody production had their optimum already after 9 days, the same phenomenon for the IgG1 response could be recognized much later (17th day for anti-BGG IgG1, 60th day for anti-DNP IgG1).