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MAIT cells: an historical and evolutionary perspective.

Olivier Lantz1,2,3, François Legoux1

  • 1Institut Curie, PSL Research University, Inserm U932, Paris, 75005, France.

Immunology and Cell Biology
|January 25, 2018
PubMed
Summary
This summary is machine-generated.

Mucosal-Associated Invariant T (MAIT) cells are abundant T cells that fight bacteria. These cells, along with NKT cells, are evolutionarily conserved and possess preprogrammed effector functions for antimicrobial defense.

Area of Science:

  • Immunology
  • Cellular Biology
  • Evolutionary Biology
Keywords:
MAITMR1phylogenypreset T cells

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Background:

  • Mucosal-Associated Invariant T (MAIT) cells are a major T-cell subset in humans, crucial for antibacterial responses.
  • MAIT cells are part of the evolutionarily conserved 'preset' T-cell family, sharing features like PLZF expression with Natural Killer T (NKT) cells.
  • Preset T cells are strategically located and equipped with versatile effector functions, including antimicrobial activity, metabolic control, and tissue repair.