Nebulized salbutamol and ipratropium bromide in asthmatic children

Varying doses of nebulized salbutamol, ipratropium bromide and a combination of both were given to 20 asthmatic children. All therapies produced effective bronchodilation. Ten mg salbutamol caused elevation of pulse rate and finger tremor whilst the duration of action of 0.6 mg salbutamol was too short. Dose-response effects were clearly seen with salbutamol but not with ipratropium bromide. A summation effect was not demonstrated when the medications were combined.