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Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
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Fetal Circulation01:14

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
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Overview of Systemic and Pulmonary Circulation01:15

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The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Related Experiment Video

Updated: Feb 15, 2026

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
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Detection of Circulating Tumor Cells Using Microfluidics.

Tiberiu A Burinaru1, Marioara Avram1, Andrei Avram1

  • 1National Institute for R&D in Microtechnologies , IMT-Bucharest , Bucharest , Romania , 077190.

ACS Combinatorial Science
|January 25, 2018
PubMed
Summary

Detecting circulating tumor cells (CTCs) in blood is crucial for cancer survival prediction. This review explores devices designed to capture these vital cancer cells, aiding clinical evaluation and treatment efficacy.

Keywords:
circulating tumor cellsepithelial-mesenchymal transitionlab-on-a-chipmetastasismicrofluidics

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Metastasis, the spread of cancer cells, is the primary cause of cancer-related mortality.
  • Circulating tumor cells (CTCs) are cancer cells in peripheral blood, indicative of metastatic potential.
  • CTC enumeration correlates with patient survival and treatment response, highlighting their clinical significance.

Purpose of the Study:

  • To review current devices for detecting and capturing circulating tumor cells (CTCs).
  • To explore various cell properties utilized by these devices for CTC isolation.
  • To discuss tumor cell dissemination, CTC biology, EMT, and clinical applications.

Main Methods:

  • Review of existing literature and technologies for CTC detection and capture.
  • Analysis of devices based on cell properties like surface markers, size, deformability, and electrical properties.
  • Discussion of the biological processes underlying CTC formation and dissemination.

Main Results:

  • Various technologies exist for CTC detection and capture, leveraging diverse cellular characteristics.
  • Improved sensitivity and specificity in CTC detection are critical for enhanced clinical evaluation.
  • Understanding CTC biology and EMT is essential for effective clinical application.

Conclusions:

  • CTC detection technologies offer promising avenues for improved cancer patient monitoring and prognosis.
  • Further development of sensitive and specific CTC detection devices is needed for widespread clinical adoption.
  • CTC analysis holds significant potential for personalized cancer treatment strategies.