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Multiple sclerosis risk perception and acceptance for Brazilian patients
Denis Bernardi Bichuetti1, Carolina Azze Franco1, Isaac Elias1
1Universidade Federal de São Paulo, Disciplina de Neurologia, São Paulo SP, Brasil.
Arquivos De Neuro-Psiquiatria
|January 25, 2018
Summary
Brazilian multiple sclerosis (MS) patients perceive disease severity and natalizumab risks similarly to Europeans but exhibit more conservative risk acceptance. This impacts treatment discussions and guideline adaptations.
Area of Science:
- Neurology
- Clinical Research
- Patient Perception Studies
Background:
- Shared decision-making in multiple sclerosis (MS) treatment is influenced by patient perceptions of disease severity and therapy risks.
- Understanding these perceptions across different countries is crucial for effective patient care.
Purpose of the Study:
- To investigate the perception of MS severity and risk acceptance related to natalizumab therapy in Brazilian patients.
- To compare these perceptions with European cohorts (Germany and Spain).
Main Methods:
- A standardized questionnaire was administered to 96 patients with relapsing-remitting MS in Brazil.
- Data were compared with existing data from two European cohorts.
Main Results:
- Multiple sclerosis was perceived as a very severe disease by Brazilian patients.
- The risk of progressive multifocal leukoencephalopathy (PML) from natalizumab was considered moderate to high.
- A risk of 1:1,000 or higher for PML deterred 76% of patients from using natalizumab.
- Older age was the only factor associated with higher risk acceptance.
- Brazilian patients demonstrated a more conservative risk-taking profile compared to German and Spanish patients.
Conclusions:
- Brazilian patients' perceptions of MS severity and natalizumab-associated PML risk align with European findings.
- However, Brazilian patients exhibit a more conservative approach to risk acceptance.
- These findings necessitate consideration in therapeutic discussions and may inform future guideline adaptations for MS management.
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