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Updated: Feb 15, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
[Biomarkers of Metabolism and Iron Nutrition]
Carmen Gloria Sermini1, María José Acevedo1, Miguel Arredondo1
1Laboratorio de Micronutrientes, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile.
Abstract:
Iron deficiency anemia is the most common nutritional deficiency worldwide, and the most susceptible groups are infants, preschoolers, women of childbearing age, and pregnant women. It is therefore essential to understand the mechanisms of regulation of iron uptake, transport, and absorption at the cellular level, particularly in enterocytes, and to identify blood biomarkers that allow the evaluation of iron status. This review describes how iron absorption is regulated by intestinal epithelial cells, the main proteins involved (iron transporters, oxidoreductases, storage proteins), and the main blood biomarkers of iron metabolism.
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