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Morbihan disease: a therapeutic challenge.

Fernanda Cabral1, Lara Caroline Lubbe1, Monisa Martins Nóbrega1

  • 1Dermatology Service at Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.

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Morbihan disease, a rare facial swelling linked to rosacea, often shows poor treatment response. A combination of deflazacort and isotretinoin proved effective, but gradual corticosteroid tapering is crucial to prevent recurrence.

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Area of Science:

  • Dermatology
  • Ophthalmology

Background:

  • Morbihan disease is a rare condition causing chronic facial edema, often linked to rosacea.
  • It presents with variable therapeutic responses and significant refractoriness.

Observation:

  • A 61-year-old male with a history of rosacea was diagnosed with Morbihan disease.
  • The patient experienced significant improvement with a combination of deflazacort and oral isotretinoin.

Findings:

  • Recurrence of facial lymphedema was observed after discontinuing corticosteroids.
  • The combination therapy demonstrated excellent efficacy in managing severe facial lymphedema.

Implications:

  • This combination therapy may be effective for severe facial lymphedema in Morbihan disease.
  • Gradual corticosteroid discontinuation is recommended to prevent disease recurrence.