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Endogenous Opiates and Behavior: 2016.

Richard J Bodnar¹

¹Department of Psychology and CUNY Neuroscience Collaborative, Queens College, City University of New York, Flushing, NY 11367, United States.

|January 26, 2018

Summary

This review covers 2016 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors affects behavior. It examines roles in pain, stress, addiction, and more.

Keywords:

Delta opioid receptor Dynorphin Endomorphin Endorphin Enkephalin Kappa opioid receptor Morphine Mu opioid receptor Nociception Orphan opioid receptor

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Area of Science:

Neuroscience
Pharmacology
Behavioral Science

Background:

The endogenous opioid system plays a crucial role in regulating various physiological and behavioral processes.
Annual reviews are essential for synthesizing the rapidly evolving research in this complex field.

Purpose of the Study:

To provide a comprehensive summary of research published in 2016 concerning the endogenous opioid system.
To analyze the behavioral effects resulting from molecular, pharmacological, and genetic manipulations of opioid system components.

Main Methods:

Review and synthesis of peer-reviewed literature published in 2016.
Categorization of studies based on the manipulation of opioid peptides, receptors, agonists, and antagonists.
Analysis of behavioral outcomes linked to these manipulations.

Main Results:

Summarized findings on the molecular-biochemical effects and neurochemical localization of endogenous opioids and their receptors.
Detailed the involvement of the opioid system in diverse behaviors including pain, stress, addiction, learning, and mood.
Highlighted research on opioid system interactions with hormones, development, and neurological functions.

Conclusions:

The endogenous opioid system remains a critical area of research with broad implications for understanding behavior and disease.
Continued investigation into opioid system modulation offers potential therapeutic targets for various conditions.
This review underscores the system's multifaceted role in health and disease, based on 2016's scientific contributions.