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Inkjet-printed Polyvinyl Alcohol Multilayers
Published on: May 11, 2017
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Inkjet printing of paracetamol and indomethacin using electromagnetic technology: Rheological compatibility and
Gayathri Kollamaram1, Simon C Hopkins2, Bartek A Glowacki3
1Bernal Institute, University of Limerick, Limerick, Ireland.
Summary
Electromagnetic inkjet printing successfully created pharmaceutical dosage forms from diverse inks, including suspensions. This technology precisely controls drug crystal forms and ensures consistent dosage, advancing personalized medicine and continuous manufacturing.
Area of Science:
- Pharmaceutical technology
- Materials science
- Chemical engineering
Background:
- Drop-on-demand inkjet printing is limited to low-viscosity formulations for pharmaceutical manufacturing and personalized medicine.
- Electromagnetic (valvejet) inkjet technology offers a potential solution for printing a wider range of pharmaceutical formulations.
Purpose of the Study:
- To investigate the application of electromagnetic inkjet printing for depositing pharmaceutical dosage forms from various viscosity solutions and suspensions.
- To explore the influence of substrate morphology and chemical interactions on the polymorphic behavior of printed paracetamol.
- To assess the accuracy, reproducibility, and adhesion properties of inkjet-printed dosage forms.
Main Methods:
- Utilized electromagnetic (valvejet) inkjet printing to deposit prototype dosage forms from solutions and suspensions.
- Conducted solid-state studies on paracetamol printed on hydroxypropyl methylcellulose (HPMC) and polyethylene terephthalate (PET) substrates.
- Evaluated the adhesion of indomethacin printed on HPMC and PET substrates using suspension inks.
Main Results:
- Successfully printed dosage forms from solutions with high viscosity and suspensions with particle sizes >2 μm.
- Demonstrated substrate-dependent polymorphic control of paracetamol, with distinct crystal forms obtained on HPMC and PET.
- Achieved high accuracy and reproducibility (RSD <4%) for low-dose (0.8 mg) formulations.
- Showcased substrate-specific adhesion of indomethacin, highlighting the importance of binder-substrate compatibility.
Conclusions:
- Electromagnetic inkjet printing is a versatile technology for producing pharmaceutical dosage forms with controlled properties.
- Substrate characteristics significantly influence the polymorphic outcomes of printed drugs.
- Tailoring ink formulations, including binders, is crucial for achieving desired adhesion on specific substrates.
- This technology holds promise for advancing personalized medicine and continuous pharmaceutical manufacturing.
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