[Intestinal immune response is regulated by gut microbe].

Area of Science:

• Microbiology
• Immunology
• Gastroenterology

Background:

• The human intestine harbors a diverse bacterial population crucial for maintaining homeostasis.
• Dysbiosis, characterized by microbial imbalance, disrupts host immunity and metabolism.
• Pathogenic bacteria can exploit dysbiosis to compromise intestinal and systemic health.

Purpose of the Study:

• To review the symbiotic interactions between the human gut microbiota and the host.
• To explore the role of dysbiosis in disease pathogenesis.
• To discuss fecal transplantation as a therapeutic strategy for dysbiosis-related diseases.

Main Methods:

• Literature review of symbiotic interactions and microbiota analysis.
• Analysis of molecular biological interactions between microbiota and host systems.
• Review of clinical applications and investigations of fecal transplantation.

Main Results:

• Microbiota analysis technologies have elucidated complex host-microbiota interactions.
• Dysbiosis is implicated in the breakdown of host immunity and metabolic homeostasis.
• Fecal transplantation shows promise as a therapeutic approach for conditions like CD infection and inflammatory bowel disease.

Conclusions:

• Understanding host-microbiota symbiosis is critical for human health.
• Dysbiosis represents a significant factor in various diseases.
• Fecal transplantation is an emerging therapeutic avenue for managing dysbiosis.