Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

8.9K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
8.9K
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Group Therapy01:26

Group Therapy

472
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
472
Behavior Therapy01:22

Behavior Therapy

752
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
752
Drug Therapy01:28

Drug Therapy

310
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
310

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to comments on "Measurable residual disease after venetoclax treatment for relapsed or refractory chronic lymphocytic leukemia in Japan".

International journal of hematology·2026
Same author

Modified short-course fludarabine-based conditioning regimen for salvage cord blood transplantation after graft failure.

International journal of hematology·2026
Same author

Extranodal natural killer/T-cell lymphoma: From fatal to curable.

CA: a cancer journal for clinicians·2026
Same author

Impact of the diagnosis-to-treatment interval on the survival of patients with CD5-positive diffuse large B-cell lymphoma.

Annals of hematology·2026
Same author

International Survey for Antiemetics in Hematopoietic Stem Cell Transplantation in the APBMT Centers.

Blood cell therapy·2026
Same author

Advances in the treatment and prognosis of aggressive NK-cell leukemia: results from the ANKL22 study.

Leukemia·2026

Related Experiment Video

Updated: Feb 15, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

NK/T Cell Lymphoma: Updates in Therapy.

Ritsuro Suzuki1

  • 1Department of Oncology and Hematology, Shimane University Hospital Cancer Center, 89-1 En-ya cho, Izumo, 693-8501, Japan. rsuzuki@med.shimane-u.ac.jp.

Current Hematologic Malignancy Reports
|January 26, 2018
PubMed
Summary

Innovative treatments are improving outcomes for extranodal NK/T cell lymphoma (ENKL). Recent strategies like L-asparaginase-containing therapies and immunotherapy offer new hope for patients with this aggressive lymphoma.

Keywords:
ChemotherapyConcurrent radiotherapyExtranodal NK cell lymphomaL-asparaginase

More Related Videos

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.0K

Related Experiment Videos

Last Updated: Feb 15, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.0K

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Extranodal NK/T cell lymphoma (ENKL), nasal type, is an aggressive lymphoma with historically poor outcomes.
  • P-glycoprotein expression contributes to chemotherapy refractoriness in ENKL.
  • Recent therapeutic advancements have significantly improved ENKL prognosis.

Purpose of the Study:

  • To review and summarize current treatment strategies for extranodal NK/T cell lymphoma (ENKL).

Main Methods:

  • Review of recent literature on ENKL treatment modalities.
  • Analysis of treatment outcomes for limited and advanced-stage ENKL.
  • Evaluation of novel therapeutic approaches including chemotherapy, stem cell transplantation, and immunotherapy.

Main Results:

  • Concurrent chemoradiotherapy with platinum and L-asparaginase is effective for limited-stage ENKL.
  • SMILE or other L-asparaginase-based regimens followed by stem cell transplantation show promise for advanced-stage ENKL.
  • Anti-PD-1 immunotherapy is effective for relapsed/refractory ENKL, improving survival rates.

Conclusions:

  • Treatment strategies for ENKL have evolved, leading to improved survival rates, particularly for limited-stage disease.
  • Further research is needed to optimize treatment for advanced-stage ENKL patients.
  • Novel therapies are transforming the prognosis of extranodal NK/T cell lymphoma.